Question
Identify this abnormality on Pap Smear:
A. Normal
B. Adenocarcinoma
C. Squamous Cell Carcinoma
D. Low Grade Squamous Intraepithelial Lesion
Show Answer
|
Correct Answer » C
Explanation
|
|
Ans:C. Squamous Cell Carcinoma.
Image shows:
1 – signs of HSIL; 2 – large nuclei and irregular chromatin deposits;3 – tumor diathesis;4 – cellular polymorphism.
Pathology of squamous cells:
- Atypical Squamous Cells-Undetermined Significance(ASC-US)
- Atypical Squamous Cells – cannot exclude HSIL (ASC-H)
- Low grade Squamous Intraepithelial Lesions (LSIL)
- High grade Squamous Intraepithelial Lesions (HSIL)
| HSIL |
LSIL |
|
| NC ratio |
~1:2 |
~1:3 |
| Nuclear membrane irregularities |
Marked – distinct notches |
Moderate |
| Chromatin granularity |
Coarse, clumped, +/-nucleolus (red) |
Coarse, no nucleolus |
| Cytoplasmic staining |
Dark |
Light |
| Perinuclear clearing |
Usually absent |
Often present |
| Binucleation |
Uncommon |
May be present |
| Maturity of squamous cell |
Normal maturity |
Hypermature (orangeophilic cell present) |
