Which of the following is the FITC for IgG-stained kidney specimen. What is this suggestive of?
A. Buerger’s disease
B. Goodpasture’s syndrome
C. Membranous glomerulonephritis
D. Systemic lupus erythematosus
Ans: C. Membranous glomerulonephritis
(Ref Robbins 9Ie p915-917; Harrison 19Ie p1843)
- The immunofluorescence above is showing granular IgG deposits along the glomerular basement membrane seen in membranous glomerulonephritis.
- Basement membrane material is laid clown between these deposits, appearing as irregular spikes protruding from the GBM.
- Immunofluorescence microscopy demonstrates that the granular deposits contain both immunoglobulins and complement