A l2-year-old boy had a cut in his forearm 4 days ago. Now the bleeding has been stopped due to granulation tissue formation. While taking a skin biopsy a part of the granulation fissue was also included in the specimen. The histology of granulation tissue is shown below. Which type of collagen is found in this granulation tissue?
A. Type I
B. Type 2
C. Type 3
D. Type 4
Ans. C. Type 3
(Ref: Robbins & Cotran,9h ed., pg. 23 & I0B)
- Granulation tissue fill in the gaps ofwound and provide the underlyingframework for the regrowth of tissue epithelium.
- During wound healing, first a provisional matrix containing fibrin, plasmafibronectin, and type III collagen is formed, but in about2 weeks this is replaced by a matrix composed primarily of type I collagen.