If changes made in some of the sequence of amino acids in the chain of human proinsulin, which of the following changes will not make any difference in the biochemical activity of the molecule?
A. Change in A1-A4
B. Change in B29,B30
C. Intra disulphide bonds
D. Change in A5 and A6
Answer-a-change in A1-A4
- A6-A11 is intra disulphide bonds.A7-B7,A20-B19 are interchain bonds
- So A1-A4 is the only amino acid not involved in insulin formation, so the best Answer is change in A1-A4