NEET PG – 84236

Which of the following is the basis for the intestine-specific expression of apoprotein B-48?

A. DNA rearrangement and loss

B. DNA rearrangement and loss

C. RNA alternative splicing

D. RNA editing

Show Answer

Correct Answer » D Explanation

The production of apoB-48 in the intestine and apoB-100 in the liver is the result of RNA editing in the intestine, where a sense codon is changed to a nonsense codon by post-transcriptional deamination of C to U.
DNA rearrangement and transposition, as well as RNA interference and alternate splicing, do alter gene expression but are not the basis of apoB-48 tissue-specific production.