Question
Which of the following is the basis for the intestine-specific expression of apoprotein B-48?
A. DNA rearrangement and loss
B. DNA rearrangement and loss
C. RNA alternative splicing
D. RNA editing
Show Answer
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Correct Answer » D Explanation |
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The production of apoB-48 in the intestine and apoB-100 in the liver is the result of RNA editing in the intestine, where a sense codon is changed to a nonsense codon by post-transcriptional deamination of C to U.
DNA rearrangement and transposition, as well as RNA interference and alternate splicing, do alter gene expression but are not the basis of apoB-48 tissue-specific production.