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NEET PG – 84288

Neelam Maurya

Question

A patient was recently started on Fluphenazine. A few weeks later, he developed tremors, rigidity, bradykinesia, and excessive salivation. The first line of management for this patient is

A. Selegiline

B. Trihexyphenidyl

C. Pramipexole

D. Amantadine

 

Show Answer

Correct Answer » B

Explanation

Ans: B. Trihexyphenidyl
* Fluphenazine may block the effects of agents used to treat Parkinson’s disease such as levodopa/carbidopa.
* Trihexyphenidyl is an antispasmodic drug that exerts a direct inhibitory effect on the parasympathetic nervous system. 
  – It also has a relaxing effect on smooth muscle. 
  – It is indicated in all forms of Parkinsonism.
* Trihexyphenidyl works as an anticholinergic and is used for the treatment of tremors, spasms, stiffness, and weak muscle control seen in patients with Parkinson’s disease.
  – It can also be used for the prevention or treatment of similar muscular conditions which are caused by certain central nervous system (CNS) drugs such as fluphenazine, haloperidol, chlorpromazine.  

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