Atypical antidepressants

Atypical Antidepressants

Trazodone & Nefazodone-

  • SARI- Serotonin Antagonist [Strong] and reuptake inhibitors [Weak]
  • Can cause priapism as a side effect

Mirtazapine –

  • NSSA – NE and Specific serotonergic antidepressant
  • Antagonism of presynaptic α2 receptors [↑ Firing of Serotonin & NE Neurons]
  • Sedation & Weight gain but no sexual side effects


  • NDRI – NE and Dopamine reuptake inhibitors
  • Favorable side effect profile with low risk on sexual side effect, weight, sedation
  • May Cause seizure in high dose.
  • Can also be used for smoking cessation

Tianeptine & Amineptine- Enhancing the reuptake of serotonin

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