Question Which of the following drugs act by inhibiting DNA replication? A. 6 Mercaptopurine B. Actinomycin D C. Mitomycin C D. Asparaginase Show Answer Correct Answer » A Explanation Ans: A. 6 Mercaptopurine 6-Mercaptopurine acts by inhibiting DNA replication. Antimetabolites: These are analogues related to the normal components of DNA or of coenzymes involved in […]
Question Which is not a prokinetic agent? A. Dopamine antagonist B. 5HT4 agonist C. Macrolides D. Diphenylmethane Show Answer Correct Answer » D Explanation Ans: D. Diphenylmethane Prokinetic drugs: These are drugs that promote gastrointestinal transit and speed gastric emptying by enhancing coordinated propulsive motility. This excludes traditional cholinomimetics and anti-ChEs which produce tonic and
Question Which of the following anticancer drugs are competitive inhibitors of tyrosine kinase – A. Imatinib and sunitinib B. Letrozole C. Bicalutamide D. Fulvestrant Show Answer Correct Answer » A Explanation Ans. is ‘a’ i.e., Imatinib and sunitinib Molecular targeted agents Tyrosine kinase inhibitors Competitive inhibitors → Imatinib, Nilotinib, Sunitinib, Dasatinib, Erlotinib, Gefitinib, Lapatinib, Sorafenib (Remember
Question What is the main feature of chemotaxis as observed in white blood cells? A. Increased random movement of neutrophils B. Increased adhesiveness to intima C. Increased phagocytosis D. Unidirectional locomotion of neutrophils Show Answer Correct Answer » D Explanation Ans: D. Unidirectional locomotion of neutrophils Chemotaxis is defined as a unidirectional movement of leukocytes
Question A 23-year-old male presented with a history of fatigue and tiredness. On investigation, he was found to have Hb values of 9gm%, MCV of 101 FL. peripheral smear examination showed microcytic RBC and hypersegmented neutrophils. Which is most probable etiology A. Lead poisoning B. Iron deficiency anemia C. Chronic alcoholism D. Hemolytic anemia
Question Which of the following is true about PAN? A. Microscopy shows fibrinoid necrosis in large arteries B. ANCA is positive C. 30% of people have HbsAg positive D. Patient have hypogammaglobulinemia Show Answer Correct Answer » C Explanation Ans: C. 30% of people have HbsAg positive Polyarteritis nodosa (PAN) is a necrotizing vasculitis involving
Question A 33-year-old man presents with a 5-week history of calf pain, swelling, and low-grade fever. Serum levels of creatinine kinase are elevated. A muscle biopsy reveals numerous eosinophils also she had peripheral blood eosinophilia. Which of the following interleukins is primarily responsible for the increase in eosinophils in this patient? A. IL 2 B.
Question Which of the following factors play a major role in the initiation of thrombus formation? A. Vasoconstriction B. Coagulation cascade activation C. Platelets activation D. Endothelial injury Show Answer Correct Answer » D Explanation Ans: D. Endothelial injury The three primary abnormalities that lead to thrombus formation (called Virchow’s triad) are (1) endothelial injury,
Question Loss of foot process is classical in case of? A. Membranous glomerulitis B. Segmental glomerulosclerosis C. IgA nephropathy D. Diabetic nephropathy Show Answer Correct Answer » B Explanation Ans: B. Segmental glomerulosclerosis Focal segmental glomerulosclerosis (FSGS) is a condition in which there is sclerosis and hyalinosis of some glomeruli and portions of their tuft
Question Which of the following will be seen on cardiac biopsy of a patient who had a post MI reperfusion injury? A. Waviness of fibres B. Eosinophilic contraction bands C. Neutrophils in cardiac cells D. Swelling of cells Show Answer Correct Answer » B Explanation Ans: B. Eosinophilic contraction bands Microscopically, irreversibly damaged myocytes
