Cerebral blood supply

Cerebral blood supply

Normal Cerebral Blood Flow = 750 mL/min (Or) 55 mL/100g/min

Note: Flow is ½ of liver blood flow

Brain O2 consumption = 46 mL/min (20% total body O2 consumption)

→ Blood supply in Grey matter > White matter.

→ Brain HIGHLY SENSITIVE to HYPOXIA, Hippocampus is the most sensitive.

Munro Kellie Doctrine:

At any point of time, “Volume of CSF, Blood, Brain Tissue” SHOULD BE CONSTANT.

Significance: On alterations of any one value  Compresses the other two values.

Ex. ↑ CSF pressure  Compress Brain tissue & Blood flow.

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