Cerebral blood supply
Normal Cerebral Blood Flow = 750 mL/min (Or) 55 mL/100g/min
Note: Flow is ½ of liver blood flow
Brain O2 consumption = 46 mL/min (20% total body O2 consumption)
→ Blood supply in Grey matter > White matter.
→ Brain HIGHLY SENSITIVE to HYPOXIA, Hippocampus is the most sensitive.
Munro Kellie Doctrine:
At any point of time, “Volume of CSF, Blood, Brain Tissue” SHOULD BE CONSTANT.
→ Significance: On alterations of any one value Compresses the other two values.
→ Ex. ↑ CSF pressure Compress Brain tissue & Blood flow.