Regulation of cerebral blood flow

Major Regulating factors – Blood pressure, PCO2 & Temperature.

The mechanism involved in each one of the factors are:

1.Blood pressure Fluctuation Bt. 65 – 140 mm Hg NO CHANGE in blood flow

AUTOREGULATION

2. PCO2

↑ PCO2 -↑ Blood Flow

3. Temperature

On ↓ Body Temp. by 1° C -↓ cerebral flow by 7% – INDUCED HYPOTHERMIA in

neurosurgical procedures – Minimizes blood loss