Etiopathogenesis of schizophrenia-Genetic factors
The etiopathogenesis of schizophrenia consists of following factors:
- Genetic
- Biochemical
- Neuropathological
Genetic Factors:
- Nine Linkage sites identified – 1q, 5q, 6p, 8p, 10p, 13q, 15q, 22q
- α- 7 nicotinic receptor
- DISC 1 [Disrupted in Schizophrenia]
- COMT [Catechol-o-methyl transferase]
- NRG 1 [Neuregulin 1]
- GRM 3 [Glutamate receptor metabotropic]
- RGS 4 [Regulator of G Signaling]
- DAOA [ D Amino Acid Oxidase Activator]