Ketone body synthesis


Ketone body synthesis


Ketogenesis:

→ Ketone Bodies are water soluble carrier form of Acetyl CoA

→ Occurs inside mitochondrial of liver cells

→ LIVER and RBCs cannot utilize Ketone Bodies

→ Fatty Acid – Albumin cannot cross blood brain barrier

Steps of Ketogenesis:

  1. Fatty Acid Oxidation
  2. Converts to Acetyl CoA X 2
  3. In the presence of thiolase it converts to Acetoacetyl CoA
  4. In the presence of synthase, it produces HMG CoA
  5. Which in the presence of lyase converts into acetoacetate
  6. That finally gives rise to betahydroxybutrate & then Acetone

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