Amyloidosis- introduction
AMYLOIDOSIS
- Amyloidosis is a group of diseases characterised by extracellular deposition of fibrillar insoluble proteinaceous substance called amyloid.
- The term amyloid was coined by Lister.
- Amyloidosis is basically a disorder of protein misfolding.
- Etiology of amyloidosis is unknown.
Physical & Chemical properties of Amyloid-
- Amyloid is composed of 2 main types of complex proteins-
- Fibril protein- 95% of amyloid
- Non- fibrilar component- P component & 5% amyloid.
- Amyloid is formed of 4-6 fibrils of 7.5- 10 nm diameter.
- Dye congo redbinds to fibrils & forms red- green dichroism on amyloid deposits.
- By X- ray crystallography & infra red spectroscopy – cross β pleated sheet produce 1000 A0 periodicity.
Exam Important
- Amyloidosis is a group of diseases characterised by extracellular deposition of fibrillar insoluble proteinaceous substance called amyloid.
- The term amyloid was coined by Lister.
- Amyloidosis is basically a disorder of protein misfolding.
- Etiology of amyloidosis is unknown.
Physical & Chemical properties of Amyloid-
- Amyloid is composed of 2 main types of complex proteins-
- Fibril protein- 95% of amyloid
- Non- fibrilar component- P component & 5% amyloid.
- Amyloid is formed of 4-6 fibrils of 7.5- 10 nm diameter.
- Dye congo red binds to fibrils & forms v
- By X- ray crystallography & infra red spectroscopy – cross β pleated sheet produce 1000 A0 periodicity.
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