CNS DEPRESSANTS: Barbiturate poisoning & Chloral hydrate

CNS DEPRESSANTS: Barbiturate poisoning & Chloral hydrate


Barbiturate  poisoning

  • It  is  mostly  suicidal, sometimes  accidental.
  • Manifestations  are due  to  excessive  CNS  depression.
  • patient  is  flabby  and  comatose  with shallow  and failing  respiration  cyanosis.
  • fall  in  BP and  cardiovascular  collapse.
  • Renal shut  down,  pulmonary complications,  bullous eruption  (barbiturate  blisters).
  • Hypothermia ,  Finally  there  is  coma.
  • Individuals treated with drugs such as barbiturates show hypertrophy of the smooth endoplamic reticulum (ER) in hepatocytes

Important  specific  features  are

  • constricted  pupil (there  may  be  alternate  constriction and dilatation,  i.e. happus reaction).
  • liquid  gold  urine.

 Treatment  includes  :

  • Gastric  lavage
  • Haemodialsis
  • Supportive  measures (O2, assissed  respiration,  maintenance  of BP).
  • Forced  alkaline  diuresis.

Chloral Hydrate

  • Chloral  hydrate  is  a colourless,  crystalline  substance  having  peculiar  pungent  odor  and pungent bitter test.
  • It  is  a powerful  hypnotic in doses  produces  natural  sleep,  but in  larger  doses  depresses  CNS  and paralyses  vital centers.
  • It  is  given  in  food  or drink  to  make person  helpless,  called  knock out drops.
  • Mickey finn is  a  combination  of alcohol and chloral  hydrate.
  • Chloral  hydrate  is  also  called  dry  wine.

Exam Important

Barbiturate  poisoning:

  • patient  is  flabby  and  comatose  with shallow  and failing  respiration  cyanosis.
  • fall  in  BP and  cardiovascular  collapse
  • Hypothermia ,  Finally  there  is  coma.
  • Individuals treated with drugs such as barbiturates show hypertrophy of the smooth endoplamic reticulum (ER) in hepatocytes.

Chloral Hydrate:

  • crystalline  substance  having  peculiar  pungent  odor  and pungent bitter test.
  • It  is  given  in  food  or drink  to  make person  helpless,  called  knock out drops.
  • Mickey finn is  a  combination  of alcohol and chloral  hydrate.
  • Chloral  hydrate  is  also  called  dry  wine
Don’t Forget to Solve all the previous Year Question asked on CNS DEPRESSANTS: Barbiturate poisoning & Chloral hydrate

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