CNS DEPRESSANTS: Barbiturate poisoning & Chloral hydrate

CNS DEPRESSANTS: Barbiturate poisoning & Chloral hydrate

Q. 1

Barbiturate ingestion is associated with hypertrophy of which cellular organelle?

 A

Mitochondria

 B

Endoplasmic reticulum

 C

Golgi apparatus

 D

Nucleolus

Q. 1

Barbiturate ingestion is associated with hypertrophy of which cellular organelle?

 A

Mitochondria

 B

Endoplasmic reticulum

 C

Golgi apparatus

 D

Nucleolus

Ans. B

Explanation:

Hypertrophy usually refers to increase in size of cells or tissues, but sometimes a subcellular organelle may undergo selective hypertrophy. Individuals treated with drugs such as barbiturates show hypertrophy of the smooth endoplamic reticulum (ER) in hepatocytes, which is an adaptive response that increases the amount of enzymes (cytochrome P-450 mixed function oxidases) available to detoxify the drugs.

Ref: Robbins, 8th edition, Chapter 1.


Q. 2

The following are true about chloral hydrate except

 A

Peculiar pungent odour

 B

Crystalline

 C

Used as hypnotic

 D

Sweetish taste

Q. 2

The following are true about chloral hydrate except

 A

Peculiar pungent odour

 B

Crystalline

 C

Used as hypnotic

 D

Sweetish taste

Ans. D

Explanation:

D i.e. Sweetish taste

Chloral hydrate (a hypnotic drug) sometimes known as dry wineQ is used in alcohol to produce sleep. Its action is so rapid that it has been given the name “knock out drops”Q. Chloral hydrate rapidly deteriorates after death. Chemical of the viscera should therefore be done as a matter of urgency.


Q. 3

True about severe barbiturate poisoning EXCEPT:

 A

Hypothermia

 B

Hypertension

 C

Coma

 D

Non-reactive pupil

Q. 3

True about severe barbiturate poisoning EXCEPT:

 A

Hypothermia

 B

Hypertension

 C

Coma

 D

Non-reactive pupil

Ans. B

Explanation:

B i.e. Hypertension

Barbiturates cause hypotension not hypertension.Q


Q. 4

Breathing seen in barbiturate poisoning:

CMC (Vellore) 14

 A

Rapid and deep

 B

Slow and shallow

 C

Normal breathing

 D

Rapid and shallow

Q. 4

Breathing seen in barbiturate poisoning:

CMC (Vellore) 14

 A

Rapid and deep

 B

Slow and shallow

 C

Normal breathing

 D

Rapid and shallow

Ans. D

Explanation:

Ans. Rapid and shallow

Quiz In Between



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