• Leprostatic drug.
  • Acedapsone – Repository form of dapsone.
  • Single IM injection maintains inhibitory levels of dapsone in tissues for up to 3 months.


Image result for moa dapsone


  • Dose of Dapsone
  • 1-2 mg/kg
  • Absorption: Completely absorbed after oral administration.


  • Approximately 70% bound to plasma protein. 
  • main metabolite, monoacetyl dapsone, is nearly 100% protein bound.


  • Acetylated in liver.
  • Variable plasma t1/2, mostly
  • Elimination takes 1-2 weeks or longer
  • Metabolites excreted in bile & urine


  • Dermatitis Herpetiformis – Drug of choice.
  • Mycobacterium leprae infections (leprosy)/hansen’s disease.
  • WHO regime for paucibacillary leprosy is 100 mg Dapsone daily + Rifampicin monthly (600 mg)
  • Acne.
  • Pneumocystis pneumonia.
  • Alternative drug for Pneumocystis treatment jirooeci infection in AIDS patients.
  • Generalised lichen planus
  • Toxoplasmosis – Prophylaxis


  • Haemolytic anaemia – Most common.
  • Gastric intolerance-nausea & anorexia, headache, paresthesias, mental symptoms & drug fever.
  • Allergic rashes, fixed drug eruption, hypermelanosis, phototoxicity & rarely exfoliative dermatitis.
  • Hepatitis & agranulocytosis.
  • DDS syndrome/Dapsone reaction/Sulfone syndrome.
  • Causes gastrointestinal irritation fever, skin rash, methemoglobinemia & hemolysis particularly in G-6-PD defrcint patients


  • Folic acid antagonists (such as pyrimethamine), nitrofurantoin, primaquine.
  • This medication may decrease the effectiveness of combination-type birth control pills.
Exam Question
  • Dapsone is used in treatment & therapeutic diagnosis of dermatitis herpetiformis.
  • Both Dapsone & Systemic steroids drugs are used in generalised lichen planus.
  • Rifampicin, dapsone and clofazimine are used if HIV infected patient develops multibacillary leprosy.
  • Hemolytic anaemia is the commonest side effect of Dapsone.
  • Dose of Dapsone is 1-2 mg/kg.
  • WHO regime for paucibacillary leprosy is 100 mg Dapsone daily + Rifampicin monthly (600 mg).
  • Fixed drug eruption (FDE) is an adverse cutaneous reaction to an ingested dapsone.
Don’t Forget to Solve all the previous Year Question asked on Dapsone

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