Degradation of Purine Nucleotides

Degradation of Purine Nucleotides


  • Human catabolises purine to uric acid.
  • In higher primates, Allantoin by enzyme uricase is the end product.
  • Adenine nucleotides catabolism- liver, heart muscle, Skeletal muscle, GIT mucosa.
  •  Guanine nucleotides catabolism- liver, spleen, kidney, pancreas, GIT mucosa.
  •  First metabolic product of purines is Xanthine.

Exam Important

  1. Human catabolise purines (adenine and guanine) to uric acid.
  2. First metabolic product of purines is xanthine.
  3. In non primate mammals, uric acid is converted to water soluble  allantion by enzyme uricase.
  4. The end product of purine catablism is uric acid, which is excreted.
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