Development of Eye

DEVELOPMENT OF EYE


DEVELOPMENT OF EYE

  • The eye is derived from 3 types of embryonic tissue:

1. Neural tube (Neuroectoderm)

2. Surface ectoderm

3. Periocular mesenchyme: Neural crest & mesoderm derivatives.        

Precursor

Derivatives

Neural ectoderm
  • Smooth muscle of the iris, optic vesicle & cup,
  • Iris epithelium,
  • Ciliary epithelium
Surface ectoderm
  • Conjunctival epithelium
  • Corneal epithelium
  • Lacrimal glands
  • Tarsal glands
  • Lens
Mesoderm
  • Extraocular muscles
  • Corneal stroma
  • Sclera
  • Iris
  • Vascular endothelium
  • Choroid part of vitreous
Neural crest
  • Corneal stroma, keratocytes & endothelium
  • Ciliary muscles

 EYE AT BIRTH

1. Anteroposterior diameter of eyeball :

  • About 16.5 mm (70% of adult size)
  • Adult size is attained by 7-8 years.

2. Corneal diameter :

  • About 10 mm.
  • Adult size (11.7 mm ) is attained by 2 tears of age.
3. Anterior chamber is shallow & angle is narrow.
4. Lens is spherical at birth.
5. Retina: 
  • Apart from macular area, the retina is fully differentiated.
  • Macula differentiates 4-6 months after birth.
6. Myelination of optic nerve fibres has reached the lamina cribrosa.
7. New born is usually hypermetropic by +2 to +3D.
8. Orbit is more divergent (50°) as compared to adult (45°)
9. Lacrimal gland is still underdeveloped & tears are not secreted.
 
EYE IN POSTNATAL
  • Fixation starts developing by 4-6 weeks
  • Critical period for development of fixation reflex is 2-4 months.
  • Development of fixation is completed by 6 months.
  • So there are 3 points to remember:
1. Fixation starts developing→ 4-6 weeks (1-1 ½ months).
2. Critical period for development→ 2-4 months.
3. Fixation development is completed → 6 months.
  • Macula is fully developed by 4-6 months.
  • Fusional reflex, stereopsis & accomodation os well developed by 4-6 months.
  • Cornea attains normal adult diameter by 2 years of age.
  • Lens grows throughout life.
  • Full visual acuity (6/6) is attained by 3 years of age.

Age

Visual acuity

New born 6/240
1 month 6/180- 6/90
4-6 months 618- 6/9
3 years 6/6
 Exam Important
  • Uveal & conjunctival melanocytes are derived from neural crest.
  • Sclera is derived from mesoderm.
  • Crystalline lens, corneal epithelium & lacrimal gland are derived from surface ectoderm.
  • Corneal stroma is made from Mesoderm.
  • Most common site for coloboma is Inferonasal.
  • The lens continues to grow throughout the lifetime.
  • Eye of new born is usually hypermetropic by +2 to +3D.
  • Normal level of visual acuity is attained by 3 yrs of age.
  • Gaze fixation starts developing in the first month & is completed in 6 months.

 

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