Different types of Fatty Oxidation

DIFFERENT TYPES OF FATTY ACID OXIDATION

Oxidation of Very Long Chain Fatty Acid-

• It takes place in Peroxisomes till Octanoyl CoA.
• Oxidation in peroxisome produces Acetyl CoA and H₂O_2.

Clinical Corelation-

1. Peroxisomal Ghost
2. Zellweger’s syndrome- is a rare inborn error of peroxisomal fatty acid oxidation.
3. Neonatal adrenoleukodystrophy
4. Infantile Refsum disease

Oxidation of Unsaturated Fatty Acid-

• It occurs in mitochondria
• The energy yield by oxidation of Unsaturated Fatty Acid is 1.5 ATP less per double bond.

Oxidation of Odd Chain Fatty Acid-

• It takes place in mitochondria
• Odd chain fatty acids are also Beta-oxidized normally but the last step produces a 3-carbon propionyl.
• This three carbon units (propionl CoA) from odd chain fatty acids is the only part of a fatty acid that is glucogenic. 

Alpha- oxidation of fatty acids–

• It occurs in endoplasmic reticulum and mitochondria

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