Different types of Fatty Oxidation

Different types of Fatty Oxidation


DIFFERENT TYPES OF FATTY ACID OXIDATION

Oxidation of Very Long Chain Fatty Acid-

  • It takes place in Peroxisomes till Octanoyl CoA.
  • Oxidation in peroxisome produces Acetyl CoA and H2O2.

Clinical Corelation-

  1. Peroxisomal Ghost
  2. Zellweger’s syndrome- is a rare inborn error of peroxisomal fatty acid oxidation.
  3. Neonatal adrenoleukodystrophy
  4. Infantile Refsum disease

Oxidation of Unsaturated Fatty Acid-

  • It occurs in mitochondria
  • The energy yield by oxidation of Unsaturated Fatty Acid is 1.5 ATP less per double bond.

Oxidation of Odd Chain Fatty Acid-

  • It takes place in mitochondria
  • Odd chain fatty acids are also Beta-oxidized normally but the last step produces a 3-carbon propionyl.
  • This three carbon units (propionl CoA) from odd chain fatty acids is the only part of a fatty acid that is glucogenic. 

Alpha- oxidation of fatty acids

  • It occurs in endoplasmic reticulum and mitochondria

Exam Important

  • Oxidation of Very Long Chain Fatty Acid- It takes place in Peroxisomes till Octanoyl CoA.
  • Oxidation in peroxisome produces Acetyl CoA and H2O2
  • Oxidation of Unsaturated Fatty Acid- It occurs in mitochondria
  • The energy yield by oxidation of Unsaturated Fatty Acid is 1.5 ATP less per double bond.
  • Odd chain fatty acids are also Beta-oxidized normally but the last step produces a 3-carbon propionyl.
  • Alpha- oxidation of fatty acids–  It occurs in endoplasmic reticulum and mitochondria.
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