Endemic ascites

Endemic ascites


Endemic ascites

  • Endemic ascites is caused by a hepatotoxin – pyrrolizidine alkaloid found in weed seeds of Crotolaria (Jhunjhunia).
Epidemiology
  • Kusmi block of Sarguja district of Madhya Pradesh during the years 1973 and 1976
  • There was an outbreak among the tribals.
  •  Mortality rate was 40%.

How Millet seeds gets contaminated:

  • Investigation by the National Institute of Nutrition concluded that this outbreak was due to intake of Millet seeds contaminated with Crotalaria seeds which form their main diet. 
  • Crotalaria occurred as a weed in areas of millet (Panicum miliare) cultivation. 

Pathology:

  • Crotalaria seeds contain pyrrolizidine alkaloids which are hepatotoxic.

Clinical features:

  •  Ascites and jaundice

Prevention

  • Preventive measures
  • Educating the people
  • Deweeding of Jhunjhunia plants which grow along with the staple food-millet.
  • Sieving to separate out the Jhunjhunia seeds from millet seeds.
Exam Question
 
  • Endemic ascites is caused by a hepatotoxin – pyrrolizidine alkaloid found in weed seeds of Crotolaria (Jhunjhunia).
  • Kusmi block of Sarguja district of Madhya Pradesh during the years 1973 and 1976
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