GRANULOCYTE STIMULATING FACTOR (G-CSF)
GRANULOCYTE COLONY-STIMULATING FACTOR
- Granulocyte-colony stimulating factor (G-CSF or GCSF)/Colony-Stimulating Factor-3 (CSF 3).
- A glycoprotein that stimulates bone marrow to produce granulocytes and stem cells.
- Produced by endothelium, macrophages, and other immune cells in response to cytokines.
- Recombinant G-CSFs include filgrastim, lenograstim, nartograstim & pegfilgrastim.
- Normally present during pregnancy.
Actions of G-CSF:
- White blood cells
- G-CSF-receptor present on precursor cells of bone marrow.
- Initiates proliferation & differentiation into mature granulocytes.
- Stimulates survival, proliferation, differentiation and function of neutrophil precursors & mature neutrophils.
- Hematopoietic system
- Potent inducer of hematopoietic stem cell mobilization from bone marrow into bloodstream.
- Can also act on neuronal cells as neurotrophic factor.
- Treatment of chemotherapy-induced neutropenia.
- Also indicated for Kostmann’s syndrome (severe congenital neutropenia).
- Used before blood donation.
- Used to increase hematopoietic stem cells quantity in donor blood, before collection by leukapheresis.
- This is particularly useful during hematopoietic stem cell transplantation.
- During stem cell transplants
- Given to receiver during hematopoietic stem cell transplantation, to compensate for conditioning regimens.
- Fastens wound healing:
- Systemic injection of G-CSF mobilizes hematopoietic stem cells to wound site and accelerate healing by clearing granulating bed.
- Acts as reliable biomarker for Early-Late Onset Neonatal Sepsis (EOS).
- Drug of choice for Neutropenia due to cancer chemotherapy is Filgrastim.
- G-CSF stimulates production of a wider variety of hematopoietic stem cells.
- Filgrastim is used in treatment of Neutropenia.
- Treatment in a child with recurrent severe bacterial infections and diagnosed of having Kostmann’s syndrome is G-CSF.
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