GRANULOMATOUS INFLAMMATION

• Granuloma is circumscribed tiny lesion composed of macrophages and lymphoid cells.
• Formation of granuloma is a Type IV granulomatous hypersensitivity reaction.

Pathogenesis-

Composition of granuloma-

• Epitheloid cells
• Multinucelated giant cells
• Lymphoid cells

Types of granuloma-

1. Immunological granuloma
2. Non- immunological granuloma- silicosis, foreign body pneumonia

Special forms of granuloma-

1. Stellate granuloma- Cat scratch disease

2. Durck’s granuloma- celebral malaria

3. Eosinophillic granuloma- Churg- strauss syndrome

4. Naked granuloma- Sarcoidosis

Systemic effects-

1. Fever- IL-1 (most important pyrogens)
2. Most important cytokine for synthesis of acute phase protein is IL-6.

Examples of granulomatous chronic inflammation-

Wound healing & Repair-

3 processes-

1. Resolution
2. Regeneration
3. Repair-

• Formation of granulation tissue is the hallmark of repair.
• Wound contraction by myofibroblast.

  Exam Important

Don’t Forget to Solve all the previous Year Question asked on Granulomatous inflammation