Hyperprolactinemia
HYPERPROLACTINEMIA
- Hyperprolactinemia is the most common pituitary hormone hypersecretion syndromes in both men and women.
- Prolactinomas are the most common cause of PRL levels > 200 μg/ L.
Etiology-
- Pregnancy & lactation
- Nipple stimulation & sexual orgasm
- Trauma
- Chronic renal failure
- Primary hypothyroidism
- Pituitary masses
- Drug induced inhibition or disruption of dopaminergic receptor function.
- Drugs- methyldopa, verapamil, Phenothiazine
Clinical features-
- Amenorrhea, galactorrhea and infertility are the hallmark in women.
- In men, loss of libido, infertility, visual loss and oligospermia.
Investigations-
- MRI
- Prolactin estimation
Treatment-
- Resection of sellar mass
- Removal of underlying cause.
Exam Important
- Hyperprolactinemia is the most common pituitary hormone hypersecretion syndromes in both men and women.
- Prolactinomas are the most common cause of PRL levels > 200 μg/ L.
Clinical features-
- Amenorrhea, galactorrhea and infertility are the hallmark in women.
- In men, loss of libido, infertility, visual loss and oligospermia.
Etiology-
- Pregnancy & lactation
- Nipple stimulation & sexual orgasm
- Trauma
- Chronic renal failure
- Primary hypothyroidism
- Pituitary masses
- Drug induced inhibition or disruption of dopaminergic receptor function.
- Drugs- methyldopa, verapamil, Phenothiazine
Investigations-
- MRI
- Prolactin estimation
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