Hyperprolactinemia

Hyperprolactinemia


HYPERPROLACTINEMIA

  • Hyperprolactinemia is the most common pituitary hormone hypersecretion syndromes in both men and women.
  • Prolactinomas are the most common cause of PRL levels > 200 μg/ L.

Etiology-

  • Pregnancy & lactation
  • Nipple stimulation & sexual orgasm
  • Trauma
  • Chronic renal failure
  • Primary hypothyroidism
  • Pituitary masses
  • Drug induced inhibition or disruption of dopaminergic receptor function.
  • Drugs- methyldopa, verapamil, Phenothiazine

Clinical features-

  • Amenorrhea, galactorrhea and infertility are the hallmark in women.
  • In men, loss of libido, infertility, visual loss and oligospermia.

Investigations-

  • MRI
  • Prolactin estimation

Treatment-

  • Resection of sellar mass
  • Removal of underlying cause.

Exam Important

  • Hyperprolactinemia is the most common pituitary hormone hypersecretion syndromes in both men and women.
  • Prolactinomas are the most common cause of PRL levels > 200 μg/ L.

Clinical features-

  • Amenorrhea, galactorrhea and infertility are the hallmark in women.
  • In men, loss of libido, infertility, visual loss and oligospermia.

Etiology-

  • Pregnancy & lactation
  • Nipple stimulation & sexual orgasm
  • Trauma
  • Chronic renal failure
  • Primary hypothyroidism
  • Pituitary masses
  • Drug induced inhibition or disruption of dopaminergic receptor function.
  • Drugs- methyldopa, verapamil, Phenothiazine

Investigations-

  • MRI
  • Prolactin estimation
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