Interstitial keratitis

Interstitial keratitis


  • Inflammation of corneal stroma without primary inflammation of epithelium or endothelium.
1. Viral:
  • HSV
  • Herpes zoster
  • EBV
  • Mumps, Measles
2. Bacterial:
  • TB
  • Syphilis
  • Lyme disease
  • Lymphogranuloma venerum
  • Leprosy
3. Other:
  • Sarcoidosis
  • Cogan’s syndrome
  •  90 % cases associated with congenital syphilis
  • Usually bilateral in congenital syphilis and unilateral in acquired syphilis
  • Hutchinson’s triad: Hutchinson’s teeth, vestibular deafness, interstitial keratitis
  • Divided into 3 stages:
  1. Initial progressive phase:
  • Keratic precipitates (KPs)
  • ground glass appearance of cornea
  • Pain, lacrimation, photobia

  2. Florid stage:

  • deep vascularization of cornea
  • Salmon patch appearance of cornea

3. Stage of regression:

  • ghost vessels in cornea
Exam Question
  • Salmon patch appearance of cornea seen in Interstitial Keratitis.
  • Interstitial keratitis is commonly seen in Congenital syphilis.
Don’t Forget to Solve all the previous Year Question asked on Interstitial keratitis

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