Metabolism of Chylomicron

Metabolism of Chylomicron


LIPOPROTEIN METABOLISM

Chylomicron Metabolism

  • Chylomicrons transport the dietry lipid from intestine to liver.
  • Function of chylomicrons is to transport exogenous triglyceride to adipose tissue (for storage).
  1. Step I- Formation of Nascent Chylomicron- contains triglyceride, cholestryl ester, cholesterol, lipid, apo B-48 & apo A.
  2. Step II- Formation of Mature Chylomicron- by receiving apo C-II and apo E from HDL.
  3. Step III- Formation of Remanant Chylomicron– Apo C-II activates Lipoprotein Lipase
  4. Step IV- Uptake of Remnant Chylomicron
  • Chylomicron remnant is taken up by the liver.
  • Uptake is mediated by apo E via two apo E dependent recptors, LDL  receptor and LDL receptor related protein-I (LRP-I).

Exam Important

  • Chylomicrons transport the dietry lipid from intestine to liver.
  • Function of chylomicrons is to transport exogenous triglyceride to adipose tissue (for storage).
  1. Step I- Formation of Nascent Chylomicron
  2. Step II- Formation of Mature Chylomicron- by receiving apo C-II and apo E from HDL.
  3. Step III- Formation of Remanant Chylomicron- Apo C-II activates Lipoprotein Lipase
  4. Step IV- Uptake of Remnant Chylomicron-
  • Chylomicron remnant is taken up by the liver.
  • Uptake is mediated by apo E via two apo E dependent recptors, LDL  receptor and LDL receptor related protein-I (LRP-I).
Don’t Forget to Solve all the previous Year Question asked on Metabolism of Chylomicron

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