Metabolism of HDL
HDL METABOLISM
- Nascent HDL is synthesized and secreted from intestine and liver.
- Nascent HDL contain phospholipids, cholesterol and Apo A.
- Lecithin cholesterol Acyl Transferase (LCAT) esterified by cholesterol.
- Apo- A- I activates LCAT.
Cholesterol is transported to liver in 2 ways-
- Indirect pathway– Cholestryl ester is transferred from HDL to VLDL and chylomicrons by cholestryl ester transfer protein (CETP)à Liver
- Direct pathway– HDL cholesterol by liver via scavenger receptors.
- HDL particles are referred to as scavangers.
- The level of HDL in serum is inversely related to the incidence of MI.
- HDL is cardioprotective and anti- atherogenic is referred to good cholesterol.
- HDL- Cholesterol appears to be the best independent predictor of coronary artery disease.
- HDL collects excess cholesterol iron tissues and transport it to liver and steroidogenic tissues. This is called Reverse cholesterol transport.
Exam Important
- Nascent HDL is synthesized and secreted from intestine and liver.
- Nascent HDL contain phospholipids, cholesterol and Apo A.
- Lecithin cholesterol Acyl Transferase (LCAT) esterified by cholesterol.
- Apo- A- I activates LCAT.
Cholesterol is transported to liver in 2 ways-
- Indirect pathway– Cholestryl ester is transferred from HDL to VLDL and chylomicrons by cholestryl ester transfer protein (CETP)à Liver
- Direct pathway– HDL cholesterol by liver via scavenger receptors.
- HDL particles are referred to as scavangers.
- The level of HDL in serum is inversely related to the incidence of MI.
- HDL is cardioprotective and anti- atherogenic is referred to good cholesterol.
- HDL- Cholesterol appears to be the best independent predictor of coronary artery disease.
- HDL collects excess cholesterol iron tissues and transport it to liver and steroidogenic tissues. This is called Reverse cholesterol transport.
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