Oxidation of Fatty acids

OXIDATION OF FATTY ACIDS

• It is the pathway for catabolism of fatty acids.
• β oxidation mainly occurs in mitochondrial matrix.

 β oxidation of fatty acids

• Most common type of fatty acid oxidation.
• Organ sites- liver, adipose tissue, muscle
• Cell organelle- mitochondria
• Two carbon at a time are cleaved at the carboxyl end of activated fatty acid generates Acetyl CoA.
• Pathway occurs in 3 stages-

1. Activation of fatty acid in the cytosol–

• Fatty acids must first be converted to an active intermediate before they can be catabolised.

• Two high energy phosphate bonds are required for activation.

2. Transport of activated fatty acid into mitochondria-

• Long chain fatty acids penetrate the Inner Mitochondrial Membrane as Carnitine.
• It is synthesized from Lysine and methionine in liver and kidney.

• Acylcarnitine is able to penetrate the inner membrane.
• In fed state, Increased Insulin/Glucagon ratio.
• Malonyl CoA is an inhibitor of Carnitine Palmitoyl Transferase (CPT-I).
• In fasting state, decreased Insulin/Glucagon ratio.

• It is the pathway for catabolism of fatty acids.
• β oxidation mainly occurs in mitochondrial matrix.
• Most common type of fatty acid oxidation.
• Organ sites- liver, adipose tissue, muscle
• Cell organeele- mitochondria
• Two carbon at a time are cleaved at the carboxyl end of activated fatty acid generates Acetyl CoA.
• Fatty acids must first be converted to an active intermediate before they can be catabolised.
• Two high energy phosphate bonds are required for activation.
• Long chain fatty acids penetrate the Inner Mitochondrial Membrane as Carnitine.
• It is synthesized from Lysine and methionine in liver and kidney.
• Acylcarnitine is able to penetrate the inner membrane.
• In fed state, Increased Insulin/Glucagon ratio.
• Malonyl CoA is an inhibitor of Carnitine Palmitoyl Transferase (CPT-I).
• In fasting state, decreased Insulin/Glucagon ratio.