Rapoport- Leubering Cycle
- Rapoport- Leubering Cycle occurs in RBCs (erythrocytes).
- In this cycle, 1,3 – BPG is converted into 2, 3 –BPG by an enzyme biphosphoglycerate mutase.
- 2,3- BPG is then converted into 3- phosphoglycerate by enzyme 2,3- biphosphoglycerate phosphatase.
Significance of Rapaport- Leubering Cycle-
- The 2, 3 – BPG combines with haemoglobin and reduces the affinity towards oxygen. So, its presence has oxyhemoglobin unloads more oxygen to the tissues.
- 2,3BPG shifts the oxygen Dissociation curve to right.
- If the glycolysis of RBCs is impaired there will be impaired synthesis of 2, 3 – BPG which causes left shift of O2 dissociation curve and increase oxygen affinity of haemoglobin.
- Under hypoxic, high altitude, fetal tissues, anaemic condition the 2, 3- BPG concentration in the RBC increases.
- Rapoport Leubering cycle occurs in erythrocytes
- 2, 3 –bisphosphoglycerate combines with hemoglobin & reduces affinity towards oxygen.
- 2,3 BPG shifts the oxygen Dissociation curve to right due to reduced affinity towards oxygen
- No ATP is generated (only one molecule generated through glycolysis in RBC utilized)
- Under hypoxic conditions, 2, 3- BPG increases in RBCs
- Cancer cells switching to glycolysis even in the presence of adequate O2 for oxidative phosphorylation c/d Warburg effect
Don’t Forget to Solve all the previous Year Question asked on Rapoport- Leubering Cycle