Regulation of Fatty Acid Synthesis
REGULATION OF FATTY ACID SYNTHESIS
- The rate limiting step is Acetyl CoA carboxylase.
- Long Term Regulation- by regulation of gene expression
- Short Term Regulation-
- Allosteric regulation- allosteric activation of Acetyl CoA Carboxylase by Citrate
- Covalent modification- Acetyl CoA Carboxylase is active in dephosphorylated state and inactive in phosphorylated state.
|
Activation of acetyl CoA Carboxylase |
Inactivation of acetyl CoA carboxylase |
|
Citrate |
Acyl CoA |
|
Insulin |
Glucagon, Epinephrine |
|
Dephosphorylation |
Phosphorylation |
Elongation of Fatty Acid-
- It occurs in endoplasmic reticulum and in some mitochondria.
- By Fatty Acid Elongase system.
Synthesis of Unsaturated Fatty Acid–
- Occurs in endoplasmic reticulum.
- By enzyme Fatty Acyl CoA Desaturase.
Exam Question
- The rate limiting step is Acetyl CoA carboxylase.
- Short Term Regulation-
- Allosteric regulation- allosteric activation of Acetyl CoA Carboxylase by Citrate
- Covalent modification- Acetyl CoA Carboxylase is active in dephosphorylated state.
|
Activation of acetyl CoA Carboxylase |
Inactivation of acetyl CoA carboxylase |
|
Citrate |
Acyl CoA |
|
Insulin |
Glucagon, Epinephrine |
|
Dephosphorylation |
Phosphorylation |
- Elongation of Fatty Acid- It occurs in endoplasmic reticulum.
- Synthesis of Unsaturated Fatty Acid–
- Occurs in endoplasmic reticulum.
- By enzyme Fatty Acyl CoA Desaturase.
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