Sjogren syndrome

SJOGREN’S SYNDROME


SJOGREN’S SYNDROME

  • Sjogren’s syndrome is an autoimmune disorder associated with parotid glands.
  • It is characterised by lymphocytic infiltration of salivary and lacrimal gland.
  • It affects women more (40- 60 years)
  • Associated with HLA- B8 & DR3.
  • Associated with RA, SLE, and primary biliary cirrhosis.

Clinical Features-

  • Dry eyes ( keratoconjuctivitis sicca)
  • Xerostomia
  • Vaginal dryness
  • Raynaud’s phenomenon
  • Lymphoma
  • Splenomegaly

The development ofLymphomas in patients with Sjogren syndrome is suggested by : –

  • Persistent parotid gland enlargement
  • Purpura
  • Leukopenia
  • Cryoglobulinemia
  • Low C4 complement levels

Investigations-

  • Schirmer test- for flow of tear
  • ESR elevated
  • Biopsy- The earliest histological finding in both the major and minor salivary glands is periductal and perivascular lymphocytic infilteration which eventually becomes extensive
  • Autoantibodies- RF, ANA, anti- Ro (SS-A), anti- La (SS- B)

Treatment-

  • Lubricants for dry eyes.
  • Xerostomia- saliva forming lubricants
  • Corticosteroids for extraglandular & musculoskeletal deformities.

Exam Important

  • Sjogren’s syndrome is an autoimmune disorder associated with parotid glands.
  • It is characterised by lymphocytic infiltration of salivary and lacrimal gland.
  • It affects women more (40- 60 years)
  • Associated with HLA- B8 & DR3.
  • Associated with RA, SLE, and primary biliary cirrhosis.

Clinical Features-

  • Dry eyes ( keratoconjuctivitis sicca)
  • Xerostomia
  • Vaginal dryness
  • Raynaud’s phenomenon
  • Lymphoma
  • Splenomegaly

The development ofLymphomas in patients with Sjogren syndrome is suggested by : –

  • Persistent parotid gland enlargement
  • Purpura
  • Leukopenia
  • Cryoglobulinemia
  • Low C4 complement levels

Investigations-

  • Autoantibodies- RF, ANA, anti- Ro (SS-A), anti- La (SS- B)
Don’t Forget to Solve all the previous Year Question asked on SJOGREN’S SYNDROME

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