SJOGREN’S SYNDROME
SJOGREN’S SYNDROME
- Sjogren’s syndrome is an autoimmune disorder associated with parotid glands.
- It is characterised by lymphocytic infiltration of salivary and lacrimal gland.
- It affects women more (40- 60 years)
- Associated with HLA- B8 & DR3.
- Associated with RA, SLE, and primary biliary cirrhosis.
Clinical Features-
- Dry eyes ( keratoconjuctivitis sicca)
- Xerostomia
- Vaginal dryness
- Raynaud’s phenomenon
- Lymphoma
- Splenomegaly

The development ofLymphomas in patients with Sjogren syndrome is suggested by : –
- Persistent parotid gland enlargement
- Purpura
- Leukopenia
- Cryoglobulinemia
- Low C4 complement levels
Investigations-
- Schirmer test- for flow of tear
- ESR elevated
- Biopsy- The earliest histological finding in both the major and minor salivary glands is periductal and perivascular lymphocytic infilteration which eventually becomes extensive
- Autoantibodies- RF, ANA, anti- Ro (SS-A), anti- La (SS- B)
Treatment-
- Lubricants for dry eyes.
- Xerostomia- saliva forming lubricants
- Corticosteroids for extraglandular & musculoskeletal deformities.
Exam Important
- Sjogren’s syndrome is an autoimmune disorder associated with parotid glands.
- It is characterised by lymphocytic infiltration of salivary and lacrimal gland.
- It affects women more (40- 60 years)
- Associated with HLA- B8 & DR3.
- Associated with RA, SLE, and primary biliary cirrhosis.
Clinical Features-
- Dry eyes ( keratoconjuctivitis sicca)
- Xerostomia
- Vaginal dryness
- Raynaud’s phenomenon
- Lymphoma
- Splenomegaly
The development ofLymphomas in patients with Sjogren syndrome is suggested by : –
- Persistent parotid gland enlargement
- Purpura
- Leukopenia
- Cryoglobulinemia
- Low C4 complement levels
Investigations-
- Autoantibodies- RF, ANA, anti- Ro (SS-A), anti- La (SS- B)
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