Stem cells

Stem cells


STEM CELLS

  • Stem cells has major 2 properties-
  • Self renewal
  • Asymmetric replication (stochastic differentiation) 

Types of Stem cells-

1. Embryogenic stem cells (ES cells)-

  • They are pluripotent (generate all cell lineages)
  • Isolated from normal blastocysts
  • Most undifferentiated stem cells.

2. Adult stem cells

  • Also called as tissue stem cells.
  • Adult stem cells occur in specialized micro environmental within organ called stem cell niches.
  • Adult stem cells are-

a) Liver stem cells-

  • At canals of Hering
  • Forms bipotent progenitor called oval cells.

b) Skin stem cells-

  • Forms bulge stem cells.

c) intestinal crypt epithelium-

  • Located above Paneth cells.

d) Skeletal muscle

  • Located at basal lamina of myotubules.
  • Called as satellite cells.

e) Cornea

  • Located limbal stem cells.

f) Bone marrow

  • Pluripotent
  • Marrow stromal cells

g) Brain

  • Located at dentate gyrus
  • When stem cells transforms to form cells characteristic of other tissues, the process is called as trans differentiation.

Exam Important

Stem cells has major 2 properties-

  • Self renewal
  • Asymmetric replication (stochastic differentiation)

Embryogenic stem cells (ES cells)-

  • They are pluripotent (generate all cell lineages)

Adult stem cells

  • Also called as tissue stem cells.
  • Adult stem cells are-

a) Liver stem cells-

  • At canals of Hering
  • Forms bipotent progenitor called oval cells.

b) Skin stem cells-

  • Forms bulge stem cells.

c) intestinal crypt epithelium-

  • Located above Paneth cells.

d) Skeletal muscle

  • Located at basal lamina of myotubules.
  • Called as satellite cells.

e) Cornea

  • Located limbal stem cells.

f) Bone marrow

  • Pluripotent
  • Marrow stromal cells

g) Brain

  • Located at dentate gyrus
  • When stem cells transforms to form cells characteristic of other tissues, the process is called as trans differentiation.

 

Don’t Forget to Solve all the previous Year Question asked on Stem cells

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