Systemic Sclerosis

Systemic Sclerosis


Systemic Sclerosis

  • Diffuse cutaneous systemic sclerosis is characterised by early pulmonary fibrosis.
  • Late stages of limited systemic sclerosis patients may develop  Pulmonary arterial hypertension (PAH),  Interstitial lung disease,  Hypothyroidism,  Primary biliary cirrhosis.
  • Limited cutaneous systemic sclerosis have Anticentromere autoantibody positivity
  • Increased serum antibodies to human cytomegalovirus are seen in Systemic Sclerosis.
  • The incidence of SSc is increased among miners exposed to silica
  • Bleomycin, pentazocine and cocaine may produce systemic sclerosis like illness
  • Secondary Raynaud’s phenomenon is associated with SLE, systemic sclerosis, Atherosclerosis, Buerger’s disease, RA.
  • Features of Systemic Sclerosis are Calcinosis;Sclerodactyly &  Raynaud’s phenomena.
  • A 35 year old lady complains dysphagia, Raynaud’s phenomenon, sclerodactyly. Investigations show antinuclear antibody. The likely diagnosis is Systemic Sclerosis.
  • ANA (antinuclear antibody) may be seen in Systemic Sclerosis.
  • Antitopoisomerase antibodies (Scl 70) are characteristic of diffuse systemic sclerosis .
  • Trunk involvement is present in generalized (diffuse) systemic sclerosis.
  • Raynaud’s phenomenon seen years before skin changes in generalized (diffuse) systemic sclerosis..
  • Calcinosis , Sclerodactyly , Hyperpigmentation (Melanin deposition) may be seen in Systemic Sclerosis.
  • The term mixed connective tissue disease is used to describe a disease with clinical features that are a mixture of the features of SLE, systemic sclerosis, and Polymyositis.
Exam Question
 
  • Diffuse cutaneous systemic sclerosis is characterised by early pulmonary fibrosis.
  • Late stages of limited systemic sclerosis patients may develop  Pulmonary arterial hypertension (PAH),  Interstitial lung disease,  Hypothyroidism,  Primary biliary cirrhosis.
  • Limited cutaneous systemic sclerosis have Anticentromere autoantibody positivity
  • Increased serum antibodies to human cytomegalovirus are seen in Systemic Sclerosis.
  • The incidence of SSc is increased among miners exposed to silica
  • Bleomycin, pentazocine and cocaine may produce systemic sclerosis like illness
  • Secondary Raynaud’s phenomenon is associated with SLE, systemic sclerosis, Atherosclerosis, Buerger’s disease, RA.
  • Features of Systemic Sclerosis are Calcinosis;Sclerodactyly &  Raynaud’s phenomena.
  • A 35 year old lady complains dysphagia, Raynaud’s phenomenon, sclerodactyly. Investigations show antinuclear antibody. The likely diagnosis is Systemic Sclerosis.
  • ANA (antinuclear antibody) may be seen in Systemic Sclerosis.
  • Antitopoisomerase antibodies (Scl 70) are characteristic of diffuse systemic sclerosis .
  • Trunk involvement is present in generalized (diffuse) systemic sclerosis.
  • Raynaud’s phenomenon seen years before skin changes in generalized (diffuse) systemic sclerosis..
  • Calcinosis , Sclerodactyly , Hyperpigmentation (Melanin deposition) may be seen in Systemic Sclerosis.
  • The term mixed connective tissue disease is used to describe a disease with clinical features that are a mixture of the features of SLE, systemic sclerosis, and Polymyositis.
Don’t Forget to Solve all the previous Year Question asked on Systemic Sclerosis

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