Vitamin A Deficiency
Vitamin A Deficiency-
- Xerophthalmia (dry eye)
- Nyctalopia
- Conjunctival xerosis
- Bitot’s spots
- Keratomalacia
- Corneal scarring
- Gonadal dysfunction
- Follicular hyperkeratosis
Vitamin A Toxicity (Hypervitaminosis A)
- Hypervitaminosis A can lead to rupture of lysosomal membrane.
- Acute toxicity- Pseudotumour cerebri (headache, dizziness, vomiting, drowsiness, blurred vision)
- Chronic toxicity- anorexia, weight loss, nausea, bone and joint pain, bone abnormalities and bony swelling.
Treatment-
- 200000 or 110mg of Retinol palmitate orally in 2 days.
- Single massive dose 100000 IU to children (6 month- 1 year) once in 6 months.
- Single massive dose 200000 IU to children (1_6 years) once in 6 months
- Required Daily Allowance of Vitamin A (μg of Retinol
Children (1-6 yrs)- 400 pg/day
- Men- 600 pg/day
- Women- 600 pg/day
- Pregnancy- 800 pg/day
- Lactation- 950 pg/day
Exam Question
- Clinical manifestations- Xerophthalmia (dry eye), Follicular hyperkeratosis
- Hypervitaminosis A can lead to rupture of lysosomal membrane.
- Acute toxicity- Pseudotumour cerebri
- Chronic toxicity- bone abnormalities and bony swelling.
- Single massive dose 100000 IU to children (6 month- 1 year) once in 6 months.
- Single massive dose 200000 IU to children (1_6 years) once in 6 months
- Required Daily Allowance of Vitamin A (μg of Retinol)
Children (1-6 yrs)- 400 pg/day
- Men- 600 pg/day
- Women- 600 pg/day
- Pregnancy- 800 pg/day
- Lactation- 950 pg/day
Don’t Forget to Solve all the previous Year Question asked on Vitamin A Deficiency
