Wound healing & repair

Wound healing & repair


Healing involves 2 processes-

1. Regeneration- results in complete restoration of original tissues.

2. Repair- results in fibrosis & scarring.

  • 2 processes in repair include-

A. Granulation tissue formation-

i) Phase of inflammation-

  • Acute inflammatory response which exudation of plasma, neutrophils within 24hours.

ii) Phase of clearance-

  • Autolytic enzymes & phagocytes clears off necrotic tissue.

iii) Granulation tissue growth consist of triad-

  • Neovascularization (angiogenesis)
  • Fibrogenesis
  • Non specific inflammation

B. Contraction of wounds

  • Scar tissue & adult skin – Type I collagen
  • Early granulation tissue- Type I & III collagen

Types of cells-

Exam Important

Repair- results in fibrosis & scarring.

Granulation tissue growth consist of triad-

  • Neovascularization (angiogenesis)
  • Fibrogenesis
  • Non specific inflammation
  1. Scar tissue & adult skin – Type I collagen
  2. Early granulation tissue- Type I & III collagen

Types of cells-

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