Wound healing & repair

Healing involves 2 processes-

1. Regeneration- results in complete restoration of original tissues.

2. Repair- results in fibrosis & scarring.

• 2 processes in repair include-

A. Granulation tissue formation-

i) Phase of inflammation-

• Acute inflammatory response which exudation of plasma, neutrophils within 24hours.

ii) Phase of clearance-

• Autolytic enzymes & phagocytes clears off necrotic tissue.

iii) Granulation tissue growth consist of triad-

• Neovascularization (angiogenesis)
• Fibrogenesis
• Non specific inflammation

B. Contraction of wounds

• Scar tissue & adult skin – Type I collagen
• Early granulation tissue- Type I & III collagen

Types of cells-

Exam Important

Don’t Forget to Solve all the previous Year Question asked on Wound healing & repair