MAO Inhibitors


MAO Inhibitors


Act by inhibiting metabolism of monoamines

Two Isoforms MAO-A [Serotonin & NE] MAO B [Dopamine]

Now Rarely used as can cause hypertensive crisis

Cheese Reaction:

  • Cheese, Red Wine, Beer contains tyramine which consumed by MAO-A in GI
  • If MAO inhibitors used then tyramine get absorbed resulting in hypertensive crisis
  • Management – Phentolamine

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