A 20 year old female is diagnosed to have molar pregnancy. All of the following are features of partial mole, EXCEPT:
Fetus is present
Amnion is present
Karyotype is usually 69 XXY
Greater risk of persistent trophoblastic disease
In a case of partial mole there is only 1-5% risk of development of persistent trophoblastic disease. There is a 15–20% risk for developing this in cases of complete mole.
Features of partial mole are:
- Karyotype is usually 69,XXX or 69,XXY
- Fetus, amnion and fetal red blood cells are often present
- Villous edema could be focal or diffuse
- Trophoblastic proliferation could be variable
- 1-5% risk of developing persistent trophoblastic disease
Ref: Cunningham F.G., Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (2010). Chapter 11. Gestational Trophoblastic Disease.