Question
Which of the following is not true about beta oxidation of fatty acids?
| A. |
ATP is utilised in the transport of fatty acid across mitochondrial membrane
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| B. |
Both CAT I and CAT II are involved in the transport of fatty acids across mitochondrial membrane
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| C. |
CoA is released in the cytosol while formation of acyl carnitine
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| D. |
Carnitine is released in the mitochondrial side
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Show Answer
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Correct Answer � A
Explanation
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– Beta oxidation occurs in the mitochondrial matrix. Long-chain fatty acids need the carnitine shuttle to enter mitochondria.
– ATP is used only for fatty acid activation in the cytosol by acyl-CoA synthetase, forming fatty acyl-CoA.
– ATP is not directly used to transport fatty acids across the mitochondrial membrane.
– Carnitine Acyltransferase I (CAT I) on the outer membrane converts fatty acyl-CoA to acyl carnitine, releasing CoA in the cytosol.
– Acyl carnitine crosses into the matrix via carnitine-acylcarnitine translocase.
– Carnitine Acyltransferase II (CAT II) on the inner membrane converts acyl carnitine back to fatty acyl-CoA and releases carnitine, which returns to the cytosol.
