Question
Which of the following circulating antibodies has the best sensitivity and sepcificity for the diagnosis of celiac disease ‑
| A. |
Anti Saccharomyces antibody
|
| B. |
Anti-tissue transglutaminase antibody
|
| C. |
Anti-gliadin antibody
|
| D. |
Anti-gliadin antibody antibody
|
Show Answer
|
Correct Answer » B
Explanation
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|
- Anti–tissue transglutaminase (tTG) IgA antibody:
- Most sensitive and specific test for celiac disease
- Sensitivity: ~95–98%
- Specificity: ~95–97%
- First-line screening test
- Tissue transglutaminase modifies gliadin → triggers immune response
Explanation of Other Options
- Option A: Anti-Saccharomyces cerevisiae antibody (ASCA)
- Seen in Crohn’s disease, not celiac
- Option C: Anti-gliadin antibody (AGA)
- Older test
- Low specificity → many false positives
- Not preferred now
- Option D: Duplicate/incorrect option
- Same as C, likely printing error
