Question
All of the following drugs cause amorphous whorl like corneal deposits except:
| A. |
Chloroquine
|
| B. |
Amiodarone
|
| C. |
Indomethacin
|
| D. |
Chlorpromazine
|
Show Answer
|
Correct Answer » D
Explanation
|
|
Corneal Verticillata (Whorl Keratopathy)
- Also called vortex keratopathy
- Characterized by whorl/spiral deposits in corneal epithelium
- Caused by cationic amphiphilic drugs → phospholipid accumulation
Drugs Causing Whorl-like Deposits
- Amiodarone (most common)
- Chloroquine / Hydroxychloroquine
- Indomethacin
- Others: Fabry disease (non-drug cause)
Why D is Correct (Exception)
- Chlorpromazine:
- Causes granular, stellate, or brown deposits
- Located in stroma/endothelium/lens
- NOT the classic epithelial whorl pattern
Hence, it is the correct “EXCEPT”.
Why C (Indomethacin) is NOT Correct
- Indomethacin can cause vortex keratopathy
- Though less common than amiodarone, it is a recognized cause of whorl pattern
Whorl (Verticillata) Deposits
- Amiodarone
- Chloroquine / Hydroxychloroquine
- Indomethacin
Non-Whorl Corneal Deposits
- Chlorpromazine → granular / stellate deposits
- Gold → chrysiasis
- Silver → argyrosis