Question
All of the following are paraneoplastic syndromes for renal cell carcinoma except –
| A. |
Polycythemia
|
| B. |
Hypercalcemia
|
| C. |
Malignant hypertension
|
| D. |
Cushing syndrome
|
Show Answer
|
Correct Answer » C
Explanation
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|
Renal cell carcinoma (RCC) is well known for producing a variety of paraneoplastic syndromes due to ectopic hormone production.
C. Malignant hypertension
- Although RCC may be associated with hypertension, it is usually due to:
- Renin secretion
- Renal ischemia
- However, malignant hypertension is not a classic or recognized paraneoplastic syndrome of RCC.
Why Other Options are Correct
A. Polycythemia
- Due to ectopic erythropoietin (EPO) production
- Leads to increased RBC mass
B. Hypercalcemia
- Due to:
- PTH-related peptide (PTHrP) secretion
- Osteolytic metastasis (less commonly)
- Common paraneoplastic feature
D. Cushing syndrome
- Due to ectopic ACTH production
- Leads to features of hypercortisolism
