Question
Which of the following is the most appropriate treatment for a patient with Toxoplasma
encephalitis?
| A. |
Pyrimethamine, sulfadiazine, and leucovorin
|
| B. |
IV aqueous crystalline penicillin G, 18 to 24 million U daily
|
| C. |
HAART
|
| D. |
Rifampin, isoniazid, pyrazinamide and emtricitabine
|
Show Answer
|
Correct Answer � A
Explanation
|
|
Pyrimethamine, sulfadiazine, and leucovorin
-
Toxoplasma gondii encephalitis (TE).
-
The initial drug of choice remains a combination of pyrimethamine, sulfadiazine, and leucovorin.
-
Pyrimethamine penetrates the brain parenchyma even in the absence of inflammation.
-
Leucovorin is used to minimize the hematologic toxicities secondary to pyrimethamine use.
