A 74-year-old man with metastatic prostate cancer develops shooting pains in his left leg and constant back pain. Further evaluation reveals a pathologic compression fracture of the lumbar spine and involvement of the nerve roots in his lower spine causing the pain. He is started on a medication to help reduce the symptoms, but a limitation of the drug is leukopenia and thrombocytopenia.
|A.||nonsteroidal anti-inflammatory drugs (NSAIDs)|
Carbamazepine is an anticonvulsant used widely as an adjuvant analgesic for neuralgic pain caused by either tumor infiltration or surgical nerve injury. Because cancer patients commonly have compromised hematologic reserve, leukopenia and thrombocytopenia caused by carbamazepine may limit its use.