Accumulation of serum amyloid protein
Accumulation of beta-2 microglobulin
Decreased uric acid excretion
Answer : C Accumulation of beta-2 microglobulin
The patient has dialysis-related amyloidosis. It is a condition in which there is the accumulation of beta-2 microglobulin.
Beta-2 microglobulin aggregates into amyloid fibers and deposits in the joint spaces in patients on long-term hemodialysis.
The treatment of systemic amyloidosis involves supportive therapy aiming to maintain the quality of life and prevent organ dysfunction.
Renal failure in a patient undergoing long-term hemodialysis can cause amyloidosis from the accumulation of light chains of the HLA 1 complex, which is normally filtered out by the kidneys. Senile amyloidosis from the deposition of transthyretin, mainly in the heart, is found in 10% to 36% of people over 80.