MCQ – 89121

 A 5-year-old African immigrant girl presents with a long history of fever and neck swelling. A Biopsy was taken and the light microscopic view is shown in the attached image. Hemogram was normal, LDH was 2300 U/L.what is the probable diagnosis and the characteristic histopathologic appearance shown in the image:

Correct Answer � A Explanation

Ans. A. Burkitt’s lymphoma ; Starry sky appearance

The first image depicts an African child with a massive neck swelling. This along with the prolonged history of fever increased LDH and the microscopic appearance of starry sky appearance /moth-eaten appearance is suggestive of Burkitt’s lymphoma. The starry sky appearance is due to the tumor cells and reactive cells with interspersed tangible body macrophages (stars).