A 5-year-old African immigrant girl presents with a long history of fever and neck swelling. A Biopsy was taken and the light microscopic view is shown in the attached image. Hemogram was normal, LDH was 2300 U/L.what is the probable diagnosis and the characteristic histopathologic appearance shown in the image:
|A.||Burkitt’s lymphoma; Starry sky appearance|
Hodgkin’s lymphoma; nodular sclerosis type-reed Sternberg cells
Rhabdomyosarcoma; Homer Wright rosettes
Diphtheria ; Chronic granulomatous lesion
Ans. A. Burkitt’s lymphoma ; Starry sky appearance
The first image depicts an African child with a massive neck swelling. This along with the prolonged history of fever increased LDH and the microscopic appearance of starry sky appearance /moth-eaten appearance is suggestive of Burkitt’s lymphoma. The starry sky appearance is due to the tumor cells and reactive cells with interspersed tangible body macrophages (stars).