Question
A 12-year-old male child presented with progressive lower limb weakness, regression of motor milestones, and 3 episodes of generalized tonic-clonic seizures in the past year. Blood workup was normal except for elevated lactic acid levels. There is a significant family history of similar complaints in the family and the family pedigree is attached. What are the most likely diagnosis and the pattern of inheritance:
| A. |
LEIGH’S disease; mitochondrial inheritance |
| B. |
Adrenoleukodystrophy; X-linked recessive inheritance |
| C. |
MELAS; mitochondrial inheritance |
| D. |
Duchene muscular dystrophy; X-linked recessive inheritance |
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