Question
In the given image, Antagonism shown by drugs A and B in the following dose-response curve (DRC) is
| A. |
Competitive antagonism
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| B. |
Noncompetitive antagonism
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| C. |
Both a and b
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| D. |
None of the above
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Show Answer
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Correct Answer � A
Explanation
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Answer A) Competitive antagonism
The parallel rightward shift of the agonist dose-response curve (DRC) is seen with competitive antagonism.
- Competitive antagonism is based on the principle that an agonist or antagonist can bind to the same recognition site(s) on the receptor, and when both agonist and antagonist are present concomitantly, they can compete for such sites.
- Non-competitive antagonism implies that the antagonist, while still opposing the action of the agonist, does so without competing with it for the binding site
