Question
Which of the following drugs shown in the graph below has highest potency
| A. |
Drug A
|
| B. |
Drug B
|
| C. |
Drug C
|
| D. |
Both Drugs A and B
|
Show Answer
|
Correct Answer � A
Explanation
|
|
Answer A)
In Log DRC, More the curve is on the left side, more potent is the drug
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
A highly potent drug (e.g., fentanyl, alprazolam, risperidone) evokes a given response at low concentrations, while a drug of lower potency (meperidine, diazepam, ziprasidone) evokes the same response only at higher concentrations. Higher potency does not necessarily mean more side effects
Schematic illustration of the dose-response curves for a series of agonists (A, B, C and D) that have the same efficacy, but differ in terms of their potency. The most potent drug (Drug A) has the lowest EC50 value, and is approximately 20-30 fold more potent than Drug D.
