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Chlamydia pneumoniae and Chlamydia psittaca

Chlamydia pneumoniae and Chlamydia psittaca

Q. 1

Which one of the following statement regarding Chlamydia pneumoniae is TRUE?

 A

Fifteen serovars have been identified as human pathogens

 B

It is transmitted through the inhalation of bird excreta

 C

The cytoplasmic inclusions present in the sputum specimen are rich in glycogen

 D

The group specific antigen is responsible for the production of complement fixing antibodies

Q. 1

Which one of the following statement regarding Chlamydia pneumoniae is TRUE?

 A

Fifteen serovars have been identified as human pathogens

 B

It is transmitted through the inhalation of bird excreta

 C

The cytoplasmic inclusions present in the sputum specimen are rich in glycogen

 D

The group specific antigen is responsible for the production of complement fixing antibodies

Ans. D
Explanation:

Chlamydiae possess group specific antigens.

These are heat-stable lipopolysaccharides with 2-keto-3-deoxyoctanoic acid as an immunodominant component.

Antibody to these genus-specific antigens are  detected by complement fixation (CF) and immunofluorescence.

 
Ref: Harrisons Internal Medicine, 18th Edition, Chapter 176; Jawetz, Melnick and Adelberg’s Medical Microbiology, 25th Edition, Chapter 27

Q. 2
 

All of the following statements regarding Chlamydia are true, except:

 A

Gram positive

 B

Trachoma

 C

Causes Psittacosis

 D

Causes Lymphogranuloma venerum

Q. 2
 

All of the following statements regarding Chlamydia are true, except:

 A

Gram positive

 B

Trachoma

 C

Causes Psittacosis

 D

Causes Lymphogranuloma venerum

Ans.
A
Explanation:

Chlamydia are gram negative, non motile, obligate intracellular parasites which multiply in the cytoplasm of host cells.

Chlamydia trachomatis serotypes A, B and C cause trachoma, L1-3 serotypes cause lymphoganuloma venerum, D-K serotypes cause genital tract infection and conjunctivitis.

Pscittacosis is caused by Chlamydia psittaci. 


Q. 3

A bird seller developed fever with chills and severe body pain. Investigation confirms the disease as ornithosis. Causative agent is:

 A

Chlamydia psittaci

 B

Burkholderia pseudomallei

 C

Coxiella burnetii

 D

Borrelia

Q. 3

A bird seller developed fever with chills and severe body pain. Investigation confirms the disease as ornithosis. Causative agent is:

 A

Chlamydia psittaci

 B

Burkholderia pseudomallei

 C

Coxiella burnetii

 D

Borrelia

Ans.
A
Explanation:
Psittacosis (parrot fever, parrot disease, or ornithosis) is caused by C. psittaci (formerly Chlamydia psittaci), an organism common to most birds and domesticated fowl. Human acquisition is from the inhalation of dust from dried bird feces, feather dust, or aerosolized avian respiratory secretions.
Psittacosis is characterized by an incubation period of 5 to 14 days followed by abrupt onset of fever, chills, cephalgia, myalgia, and generalized malaise.
 
Melioidosis is a potentially serious illness caused by the gram-negative, saprophytic bacterium Burkholderia pseudomallei (formerly Pseudomonas pseudomallei).
 
The agent of Q fever is Coxiella burnetii, a small intracellular microorganism that only recently was grown in cell-free medium. C. burnetii, a pleomorphic coccobacillus with a gram-negative cell wall.
 
Relapsing fever is a vector-borne disease caused by spirochetes of the genus Borrelia.
 
Ref: Brooks G.F., Carroll K.C., Butel J.S., Morse S.A., Mietzner T.A. (2013). Chapter 27. Chlamydia Spp.. In G.F. Brooks, K.C. Carroll, J.S. Butel, S.A. Morse, T.A. Mietzner (Eds), Jawetz, Melnick, & Adelberg’s Medical Microbiology, 26e.

Q. 4

Which one of the following statements is true regarding Chlamydia pneumoniae –

 A

Fifteen serovars have been identified as human pathogens

 B

Mode of transmission is by the airborne bird excreta

 C

The Cytoplasmic inclusions present in the sputum specimen are rich in glycogen

 D

The group specific antigen is responsible for the production of complement fixing antibodies

Q. 4

Which one of the following statements is true regarding Chlamydia pneumoniae –

 A

Fifteen serovars have been identified as human pathogens

 B

Mode of transmission is by the airborne bird excreta

 C

The Cytoplasmic inclusions present in the sputum specimen are rich in glycogen

 D

The group specific antigen is responsible for the production of complement fixing antibodies

Ans.
D
Explanation:

Ans. is ‘d’ i.e., The group specific antigen is responsible for the production of complement fixing antibodies

Chlamvdial antigens

.   Chlamydiae possess three major kinds of antigen. The first is the heat stable, genus (group) specific antigen common to all chlamydiae. This is a lipopolysaccharide resembling the L.P.S. of enteric Gram negative bacilli. This is present in all stages of the developmental cycle and can be identified by complement fixation test.


Q. 5

Chlamydia psittacosis all are true except – 

 A

Acquired from bird’s droppings

 B

Causes urethreitis

 C

Causes pneumonia

 D

Treatment is tetracycline

Q. 5

Chlamydia psittacosis all are true except – 

 A

Acquired from bird’s droppings

 B

Causes urethreitis

 C

Causes pneumonia

 D

Treatment is tetracycline

Ans.
B
Explanation:

PSITTACOSIS

  • Chlamydia psittaci causes psittacosis, a febrile illness characterized by pneumonitis and systemic menifestations.
  • Human infection is acquired from inhalation of aerosols liberated from birds (parrots) dropping and nasal discharge.

Q. 6

An association of which of the following bacteria has been suggested with atherosclerosis:

 A

Staphylococcus Aureus

 B

Streptococcus Pneumoniae

 C

Chlamydia Pneumoniae

 D

Aspergillus Fumigatus

Q. 6

An association of which of the following bacteria has been suggested with atherosclerosis:

 A

Staphylococcus Aureus

 B

Streptococcus Pneumoniae

 C

Chlamydia Pneumoniae

 D

Aspergillus Fumigatus

Ans.
C
Explanation:

Evidence for Chlamydia Pneumoniae thus far presents the strongest association with human atherosclerosis.



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