Forms of Amyloid
The accepted nomenclature of amyloidosis is AX. What stands for A and X:
| A |
A-Amyloid X protein in the fibril |
|
| B |
A- Amyloid X- beta pleated structure |
|
| C |
A-Amyloid X- helical structure |
|
| D |
A- Amyloid X -birefringent |
The accepted nomenclature of amyloidosis is AX. What stands for A and X:
| A |
A-Amyloid X protein in the fibril |
|
| B |
A- Amyloid X- beta pleated structure |
|
| C |
A-Amyloid X- helical structure |
|
| D |
A- Amyloid X -birefringent |
Amyloid diseases are classified according to whether they are systemic or localized, acquired or inherited.
In hemodialysis associated amyloidosis, which of the following is seen
| A |
Transthyretin |
|
| B |
Beta-2 microglobulin |
|
| C |
SAA |
|
| D |
Alpha microglobulin |
In hemodialysis associated amyloidosis, which of the following is seen
| A |
Transthyretin |
|
| B |
Beta-2 microglobulin |
|
| C |
SAA |
|
| D |
Alpha microglobulin |
Ans. is ‘b’ i.e., B2 microglobulin
Amyloid (AA) originates from –
| A |
RBC |
|
| B |
Plasma cell |
|
| C |
Reticulo-endothelial cell |
|
| D |
Lymphocytes |
Amyloid (AA) originates from –
| A |
RBC |
|
| B |
Plasma cell |
|
| C |
Reticulo-endothelial cell |
|
| D |
Lymphocytes |
Ans. is ‘c’ i.e., Reticulo-endothelial cell
o SAA is produced in liver as an acute phase reactant in inflammatory process.
o The SAA is released into the circulation is an amyloid precursor and is transformed to AA-amyloid in lysosomes of macrophages and other cells of reticuloendothelial system.
AL type of amyloid is seen in –
| A |
Medullary caracinoma thyroid |
|
| B |
Primary amyloidosis |
|
| C |
Multiple myeloma |
|
| D |
b and c |
AL type of amyloid is seen in –
| A |
Medullary caracinoma thyroid |
|
| B |
Primary amyloidosis |
|
| C |
Multiple myeloma |
|
| D |
b and c |
Ans. is ‘b’ i.e., Primary amyloidosis & ‘c’ i.e., Multiple myeloma
Deposition of protein ‘A beta 2m’ is seen in which clinicopathologic category of amyloidosis –
| A |
Familial Mediterranean fever |
|
| B |
Hemodialysis associated |
|
| C |
Senile cerebral |
|
| D |
Systemic senile |
Deposition of protein ‘A beta 2m’ is seen in which clinicopathologic category of amyloidosis –
| A |
Familial Mediterranean fever |
|
| B |
Hemodialysis associated |
|
| C |
Senile cerebral |
|
| D |
Systemic senile |
Ans. is ‘b’ i.e., Hemodialysis associated
